Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: Results from two Australian studies and an additional validation set

J Beesley; SJ Jordan; AB Spurdle; H Song; SJ Ramus; SK Kjaer; E Hogdall; RA DiCioccio; V McGuire; AS Whittemore; SA Gayther; PDP Pharoah; PM Webb; G Chenevix-Trench; D Bowtell; A Green; A DeFazio; D Gertig; N Traficante; S Moore; J Hung; S Fereday; K Harrap; T Sadkowsky; A Mellon; R Robertson; T Vanden Bergh; J Maidens; K Nattress; YE Chiew; A Stenlake; H Sullivan; B Alexander; P Ashover; S Brown; T Corrish; L Green; L Jackman; K Martin; B Ranieri; J White; V Jayde; L Bowes; P Mamers; T Schmidt; H Shirley; S Viduka; H Tran; S Bilic; L Glavinas; A Proietto; S Braye; G Otton; T Bonaventura; J Stewart; M Friedlander; D Bell; S Baron-Hay; A Ferrier; G Gard; D Nevell; B Young; C Camaris; R Crouch; L Edwards; N Hacker; D Marsden; G Robertson; P Beale; J Beith; J Carter; C Dalrymple; A Hamilton; R Houghton; P Russell; A Brand; R Jaworski; P Harnett; G Wain; A Crandon; M Cummings; K Horwood; A Obermair; D Wyld; J Nicklin; L Perrin; B Ward; M Davy; C Hall; T Dodd; T Healy; K Pittman; D Henderson; S Hyde; J Miller; J Pierdes; P Blomfield; D Challis; R McIntosh; A Parker

Journal article

Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: Results from two Australian studies and an additional validation set

J Beesley, SJ Jordan, AB Spurdle, H Song, SJ Ramus, SK Kjaer, E Hogdall, RA DiCioccio, V McGuire, AS Whittemore, SA Gayther, PDP Pharoah, PM Webb, G Chenevix-Trench, D Bowtell, A Green, A DeFazio, D Gertig, N Traficante, S Moore Show all

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2007

DOI: 10.1158/1055-9965.EPI-07-0542

Abstract

Although some high-risk ovarian cancer genes have been identified, it is likely that common low penetrance alleles exist that confer some increase in ovarian cancer risk. We have genotyped nine putative functional single-nucleotide polymorphisms (SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 cases and 1,821 controls of Caucasian origin. Genotype frequencies in cases and controls were compared using logistic regression. The only SNP we found to be associated with ovarian cancer risk in both of these two studies was ..

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